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KMID : 0602620010070020195
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Korean Journal of Hepatology
2001 Volume.7 No. 2 p.195 ~ p.200
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A Case of Severe Chronic Active Epstein-Barr Virus Infection with Hepatic Involvement Confirmed by In Situ Hybridization
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이태윤/Tae Yoon Lee
이한주/오태훈/송병철/정영화/이영상/유은실/박찬정/서동진/Han Chu Lee/Tae Hoon Oh/Byung Cheol Song/Young-Hwa Chung/Yung Sang Lee/Eun Sil Yu/Chan Jung Park/Dong Jin Suh
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Abstract
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Epstein-Barr virus (EBV) infection is associated with diverse clinical manifestations. Hepatic involvement by EBV can cause a broad spectrum of histologic and clinical features ranging from acute hepatitis through lymphoproliferative disorders to
lymphoma. However, severe chronic active EBV infection with hepatic involvement in adults is quite rare. EBV infection can be demonstrated by serologic test or molecular biologic techniques. In situ hybridization can demonstrate the EBV infection.
It has the advantage of precise localization of the virus in infected tissues or tumors. Here we will describe a 46-year-old female who was admitted to our hospital because of general weakness, ready fatiguing, and jaundice. A bone marrow biopsy
revealed reactive histiocytosis with hemophagocytosis. A liver biopsy revealed lymphocyte infiltration to portal areas and sinusoids, periportal and pericellular fibrosis, mild cholestasis, and micro-and macro-vesicular fatty change. Although the results
of the serologic tests were inconclusive, in situ hybridization studies which were performed on liver biopsy tissue revealed the expression of Epstein-Barr virus-encoded RNA 1 transcripts in lymphocytes infiltrating to hepatic sinusids.
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KEYWORD
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